245 OXIDIZED LOW DENSITY LIPOPROTEIN (OX-LDL) INDUCES HYPERTROPHIC CHONDROCYTE-LIKE PHENOTYPES IN CULTURED BOVINE ARTICULAR CHONDROCYTES
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منابع مشابه
Oxidized Low-density Lipoprotein Binding to Lectin-like Ox-ldl Receptor-1 Upregulates Vascular Endotherial Growth Factor Expression in Cultured Bovine Articular Chondrocytes through Ppar-γ Activation
INTRODUCTION: It has been demonstrated that vascular endothelial growth factor (VEGF) and its receptors (VEGFR-1 and 2) are expressed in human osteoarthritis (OA) chondrocytes, and that treatment of cultured OA chondrocytes with VEGF enhances production of matrix metalloproteinase (MMP)-1 and MMP-3 but not tissue inhibitor of metalloproteinase (TIMP)-1 or -2 [1], suggesting that VEGF and its re...
متن کاملLectin-like oxidized low density lipoprotein receptor 1 (LOX-1) expression in human articular chondrocytes.
OBJECTIVE To investigate the involvement of oxidized low density lipoprotein (ox-LDL) and the expression of its receptor lectin-like oxidized low density lipoprotein receptor 1 (LOX-1) in osteoarthritis, by determining the ox-LDL in synovial fluid and the expression of LOX-1 mRNA and protein in osteoarthritic as well as normal cartilage. In addition, the effect of ox-LDL on chondrocyte viabilit...
متن کاملOxidized low density lipoprotein (ox-LDL) and its scavenger receptor LOX-1 expression in osteoarthritis
Oxidized low density lipoprotein (ox-LDL) and its scavenger receptor LOX-1 expression in osteoarthritis Aspasia Tsezou1,2,3, Theodora Simopoulou1, Lazaros Poultsides4, Sokratis Varitimidis4, Konstantinos N. Malizos3,4 1Department of Cytogenetics and Molecular Genetics, University of Thessalia, Larissa, Greece; 2Department of Biology, University of Thessalia, Larissa, Greece; 3Institute for Biom...
متن کاملMicroarray analysis of ox-LDL (oxidized low-density lipoprotein)-regulated genes in human coronary artery smooth muscle cells
Recent studies suggest that circulating LDL (low-density lipoproteins) play a central role in the pathogenesis of atherosclerosis, and the oxidized form (ox-LDL) is highly atherogenic. Deposits of ox-LDL have been found in atherosclerotic plaques, and ox-LDL has been shown to promote monocyte recruitment, foam cell formation and the transition of quiescent and contractile vascular SMCs (smooth ...
متن کاملOxidized low-density lipoprotein induces inflammatory responses in cultured human mast cells via Toll-like receptor 4.
BACKGROUND/AIMS Oxidized low-density lipoprotein (ox-LDL) is a powerful atherogen. Toll-like receptor 4 (TLR4) has a pathophysiological role in regulating inflammatory responses and atherosclerosis. Mast cells can infiltrate into the atheromatous plaque and secrete various pro-inflammatory cytokines, which significantly amplify the atherogenic processes and promote plaque vulnerability. Small i...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2009
ISSN: 1063-4584
DOI: 10.1016/s1063-4584(09)60267-3